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Single cell fluorescence in situ hybridization in microfluidic droplets
Single cell fluorescence in situ hybridization in microfluidic droplets
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机译:微流控液滴中的单细胞荧光原位杂交
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摘要
The invention provides a device, method, and system for high throughput detection of nucleic acid expression in individual cells. Cells are encapsulated in aqueous microdroplets which are merged with a biocompatible matrix, allowing on-chip fluorescence in situ hybridization on both adherent and non-adherent cells. The invention also provides multiplexed detection of nucleic acids, proteins, and cellular activity. The device and methods can be used to assess cellular interactions and to test the effects of antitumor agents.
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