SHARPLESS ASYMMETRIC EPOXIDATION REACTION USING FLOW REACTOR

摘要

PROBLEM TO BE SOLVED: To provide a method for efficiently progressing a Sharpless asymmetric epoxidation even without adding molecular sieves.;SOLUTION: The method for producing an optically active epoxyalcohol compound includes mixing an allyl alcohol compound, a titanium tetraalkoxide in a catalytic amount, an optically active tartaric acid ester in a catalytic amount, and an oxidizing agent, in a solvent by using a flow-type reactor (flow reactor). The oxidizing agent is preferably tert-butyl hydroperoxide or cumene hydroperoxide.;COPYRIGHT: (C)2013,JPO&INPIT