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THYROTROPIN-RELEASING HORMONE ANALOG AND METHOD OF USE
THYROTROPIN-RELEASING HORMONE ANALOG AND METHOD OF USE
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机译:促甲状腺激素释放激素类似物及其使用方法
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摘要
PROBLEM TO BE SOLVED: To provide a compound that is effective in reducing blood glucose level in patients suffering from the loss of pancreatic endocrine beta cell function, without affecting thyroid function and without bringing about other undesirable side effects.SOLUTION: The compound is represented by the following formula (I), wherein X is alkyl, alkenyl, alkynyl, heterocycloalkyl, or the like; Ys are each independently H, alkyl, alkenyl, or the like; and Ar group is alkyl, alkoxy, heteroaryl, or the like. The compound is used for modulating the blood glucose by treating or preventing pancreas-related disorders with the thyrotropin-releasing hormone (TRH) or TRH derivatives, especially used for the treatment or prevention of diabetes mellitus, pancreatic islet destruction, pancreatic beta cell malfunction, and hyperglycemia-related malfunction.
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