TRANSGENIC NON-HUMAN MAMMAL COMPRISING POLYNUCLEOTIDE ENCODING HUMAN OR HUMANIZED C5aR

摘要

PROBLEM TO BE SOLVED: To provide a transgenic non-human mammal having somatic cells and germ-line cells including a stable built-in type polynucleotide encoding a human or humanized C5aR.SOLUTION: The invention relates to use of the transgenic non-human mammals for screening agonists, inverse agonists and antagonists of human C5aR, and for testing efficacy of C5aR agonists, inverse agonists and antagonists in various animal models of disease.