RNA interference-mediated inhibition of high affinity IgE receptor α chain (FCεR1α) gene expression using small interfering nucleic acids (siNA)

摘要

The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of FCepsilonR1alpha gene expression and/or activity, and/or modulate a FCepsilonR1alpha gene expression pathway. Specifically, the invention relates to doublestranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against FCepsilonR1alpha gene expression.