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LUNG CANCER DIAGNOSTIC POLYPEPTIDE, METHOD FOR DETECTING LUNG CANCER, AND METHOD FOR EVALUATING THERAPEUTIC EFFECT

机译:肺癌诊断多肽,检测肺癌的方法和评估治疗效果的方法

摘要

PROBLEM TO BE SOLVED: To provide a novel biomarker which can be applied in non-small cell lung cancer diagnosis, in particular, even in early lung cancer diagnosis, since, while SCC, SLX, NSE and ProGRP, besides CEA and CYFRA, are clinically used as tumor markers that can be measured in serum and plasma of lung cancer, NSE and ProGPR are specific to small cell lung cancer and cannot detect non-small cell lung cancer, and, in CEA, CYFRA, SCC and SLX, sensitivity and specificity for detecting non-small cell lung cancer are low and lung cancer at an early stage cannot be detected, so that such tumor markers cannot be applied for use in early lung cancer diagnosis.;SOLUTION: In a method for detecting lung cancer, a lung cancer diagnostic polypeptide including a specific amino acid sequence is detected or measured by mass spectrometry.;COPYRIGHT: (C)2012,JPO&INPIT
机译:要解决的问题:提供一种新型的生物标志物,可将其用于非小细胞肺癌的诊断,尤其是在早期肺癌的诊断中,因为SCE,SLX,NSE和ProGRP除了CEA和CYFRA之外, NSE和ProGPR在临床上可用作可在肺癌血清和血浆中测量的肿瘤标志物,对小细胞肺癌具有特异性,不能检测非小细胞肺癌,并且在CEA,CYFRA,SCC和SLX中,敏感性和检测非小细胞肺癌的特异性很低,无法检测到早期肺癌,因此此类肿瘤标记物不能用于早期肺癌诊断。解决方案:在检测肺癌的方法中,质谱法检测或测量包含特定氨基酸序列的肺癌诊断多肽。;版权所有:(C)2012,JPO&INPIT

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