METHOD FOR EVALUATING PREDISPOSITION TO PEDIATRIC SOLID TUMOR OR ESOPHAGEAL CANCER, EVALUATION KIT, AGENT FOR THE SAME, AND METHOD FOR SELECTING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a method for evaluating a predisposition to pediatric solid tumor or esophageal cancer, an evaluation kit, an agent for the same, and a method for selecting the same.SOLUTION: The method for determining whether or not a subject has the predisposition capable of generating pediatric solid tumor or esophageal cancer has a process of detecting a mutation of an ALK gene using a sample containing a human gene of the subject. Regarding the detection of the mutation of the ALK gene, when the SNP or genetic polymorphism having a relation of linkage disequilibrium to the same is detected, particularly the existence of the SNP generating amino acid mutation of either one of A1280V, R1192G and A876T is detected, one can evaluate that the subject has the predisposition capable of generating pediatric solid tumor or esophageal cancer.