Cell invasion probe, cell invasion device having the cell invasion probe, and detailed invasion method

摘要

PPROBLEM TO BE SOLVED: To obtain a probe for cell invasion which invades cells, while suppressing the influence on cell membranes, as much as possible, without causing the cells to be killed, and to provide a cell invasion apparatus. PSOLUTION: The probe for cell invasion is disposed facing cells S that are being cultured on a substrate 2 in a liquid, being relatively movable in X and Y-directions, in parallel with the surface of the substrate and in a Z direction, perpendicular to the X and Y-directions; and the probe is equipped with an exploring needle 3a having a sharpened tip that is punctured into cells, and a lever part 3b for supporting the exploring needle in a cantilever state and a lipid bimolecular membrane 3c formed on the external surface of the exploring needle. When the exploring needle punctures the cells, the lipid bimolecular membrane fuses with cell membranes on the surfaces of the cells and is integrated. PCOPYRIGHT: (C)2008,JPO&INPIT