ANIMAL MODEL FOR PROTEASE ACTIVITY AND LIVER DAMAGE

摘要

PROBLEM TO BE SOLVED: To provide a non-transgenic, non-human animal useful as a model for protease activity and for liver damage, including steatosis.SOLUTION: The invention relates to a non-transgenic, non-human mammal whose liver is targeted for expression of exogenous protein with a construct comprising a promoter operably linked to DNA expressing a protease, and wherein the protease is linked to a sequence that is cleavable by the protease, and wherein the sequence is linked to a reporter. Most preferably, the mammal is a mouse.