RIBOSWITCH, STRUCTURE-BASED COMPOUND DESIGN WITH RIBOSWITCH, AND METHOD AND COMPOSITION FOR USE OF AND WITH RIBOSWITCH

摘要

PROBLEM TO BE SOLVED: To provide uses of riboswitches and modified versions of riboswitches as designer genetic switches that are controlled by specific effector compounds.SOLUTION: Natural switches are targets for antibiotics and other small molecule therapies. In addition, the architecture of riboswitches allows actual pieces of the natural switches to be used to construct new non-immunogenic genetic control elements. The changed switches become part of a therapy regimen-turning on, or off, or regulating protein synthesis. Newly constructed genetic regulation networks can be applied in such areas as living biosensors, metabolic engineering of organisms, and in advanced forms of gene therapy treatments. Compounds can be used to stimulate, active, inhibit and/or inactivate riboswitches. Atomic structures of riboswitches can be used to design new compounds to stimulate, active, inhibit and/or inactivate riboswitches.