MUCOSAL DTPA VACCINE

摘要

PROBLEM TO BE SOLVED: To provide effective mucosal DTP combination vaccines.SOLUTION: Mucosal DTPa vaccines, especially intranasal vaccines, include (a) a diphtheria antigen, a tetanus antigen and an acellular pertussis antigen, and (b) either detoxified form of cholera toxin (CT) and E.coli heat labile toxin (LT). Component (b) acts as a mucosal adjuvant. The acellular pertussis antigen preferably includes pertussis holotoxin (PT) and filamentous haemagglutinin (FHA) and, optionally, pertactin. The mucosally-delivered combined DTPa formulation can generate a level of protection against B. pertussis infection equivalent to that observed by alum-adjuvanted parenteral administration.