N-(1-(1-BENZYL-4-PHENYL-1H-IMIDAZOL-2-YL)-2,2-DIMETHYLPROPYL)BENZAMIDE DERIVATIVE AND RELATED COMPOUND AS KINESIN SPINDLE PROTEIN (KSP) INHIBITOR FOR TREATMENT OF CANCER

摘要

PROBLEM TO BE SOLVED: To provide KSP inhibitors that are effective in vivo inhibitors of KSP and KSP-related proteins.SOLUTION: There are disclosed substituted imidazole compounds which modulate the activity of KSP and are useful for the treatment of cancer and are represented by the formula (I), wherein: Ris selected from the group consisting of aminoacyl, acylamino, carboxyl, carboxyl ester, aryl, and alkyl optionally substituted with hydroxy or halo; Ris selected from the group consisting of hydrogen, alkyl, and aryl; Ris selected from the group consisting of hydrogen and-X-A, wherein X is selected from the group consisting of-C(O)-, -C(S)-, -S(O)-, -S(O)-, and-S(O)-N(R)-, where R is hydrogen or alkyl.