Lung and breast cancer or liver metastases analysis for animal models

摘要

PROBLEM TO BE SOLVED: To produce a lung or liver metastasis animal model useful for analyzing the mechanism or cause of the metastasis of breast cancer to the lung or liver, and to provide new means for screening an inhibitory agent of the metastasis of the breast cancer to the lung and/or liver.;SOLUTION: This metastasis animal model of the breast cancer to the lung and/or liver is produced by administering highly metastatic mouse breast cancer cells derived from the mouse breast cancer cell 4T1 and having an enhanced lung or liver metastatic ability to mice, and also the highly metastatic mouse breast cancer cells are used for the screening of an inhibitor of the metastasis of the breast cancer cells to the lung and/or liver.;COPYRIGHT: (C)2009,JPO&INPIT