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Method for diagnosis of autoimmune disease patient, in vitro diagnostic agent and therapeutic agent thereof

机译:诊断自身免疫病患者的方法,体外诊断剂及其治疗剂

摘要

The present invention provides a method for diagnosing a patient in which antibody treatment and / or endotoxin absorber treatment is effective, and an in vitro diagnostic agent used for such diagnosis, and is particularly effective for such autoimmune disease patients. And / or therapeutic method, comprising selecting a patient who is negative for DR15 at the HLA-type DR locus expressed in a patient's immune system cells, and / or Method for diagnosing autoimmune disease patient effective for endotoxin absorber treatment, labeled primer of HLA type DR gene, and in vitro of patient with such autoimmune disease comprising stationary phase probe complementary to DR15 gene as essential elements An autoimmune disease negative for HLA-DR15 expressed in immune system cells, comprising a diagnostic agent, and further an immunoglobulin and / or endotoxin absorber Shah therapeutic agents, and to a method of treating autoimmune disease, which comprises orally administering the therapeutic agent for such autoimmune disease patients.
机译:本发明提供了一种用于诊断其中抗体治疗和/或内毒素吸收剂治疗有效的患者的方法,以及用于这种诊断的体外诊断剂,并且对于这种自身免疫疾病患者特别有效。和/或治疗方法,包括选择在患者的免疫系统细胞中表达的HLA型DR位点DR15阴性的患者,和/或对内毒素吸收剂治疗有效的自身免疫病患者的诊断方法,标记的HLA型引物DR基因,以及患有这种自身免疫性疾病的患者的体外,其包含与DR15基因互补的固定相探针作为必需成分一种免疫系统细胞中表达的HLA-DR15阴性的自身免疫性疾病,包括诊断剂,以及免疫球蛋白和/或内毒素吸收剂Shah治疗剂,以及一种治疗自身免疫性疾病的方法,其包括对这类自身免疫性疾病患者口服治疗剂。

著录项

  • 公开/公告号JPWO2010123069A1

    专利类型

  • 公开/公告日2012-10-25

    原文格式PDF

  • 申请/专利权人 アサマ化成株式会社;

    申请/专利号JP20110510362

  • 申请日2010-04-22

  • 分类号C12Q1/68;A61K39/395;A61K45;A61P37/02;A61P29;A61P19/02;G01N33/50;G01N33/53;C12N15/09;

  • 国家 JP

  • 入库时间 2022-08-21 17:37:51

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