首页>
外国专利>
Transdermal delivery of hormones without the need for penetration enhancers
Transdermal delivery of hormones without the need for penetration enhancers
展开▼
机译:透皮递送激素,无需渗透促进剂
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to a patch comprising a drug-containing layer with low content of hormones, such as gestodene, and optionally an estrogen (e.g. ethinyl estradiol). Upon administering the patch to a woman, plasma levels of at least 1.0 ng/ml of Gestodene is achieved at steady state conditions without the need of incorporating penetration enhancers or permeation enhancers in the drug-containing layer. Satisfactorily plasma levels of the hormones is also achieved throughout a period of at least 1 week, making the patch applicable for being used in female contraception with the concept of administering the patch ones weekly.
展开▼
机译:本发明涉及一种贴剂,该贴剂包括具有低含量的激素例如孕二烯烯的含药层,以及任选地雌激素(例如乙炔基雌二醇)。在将贴剂施用于女性时,在稳态条件下血浆水平至少达到1.0 ng / ml的Gestodene,而无需在含药层中掺入渗透促进剂或渗透促进剂。在至少1周的时间内也达到了令人满意的血浆血浆水平,使得该贴剂适用于女性避孕,其概念是每周服用一次。
展开▼