Fertility testing method, fertility test kit, polynucleotides, polypeptides, and antibodies

摘要

Estimation of fertility may have been based on the fusion ability to egg in the sperm, fertility testing and diagnostic methods and allows the identification of the causes of infertility, the present invention is pregnant and polynucleotides as well as used in the method and an object thereof is to provide a test kit . For biological sample taken from a person, has a detection step of detecting the presence or absence of a mutation or deletion of PGAM4 human genes, the present invention, the gene or nucleotide sequence fertility testing and diagnosis methods, the human wild-type PGAM4 gene In a polynucleotide consisting of the nucleotide sequence of the translated region of a polynucleotide consisting of a nucleotide sequence of consecutive 10 to 100, including the mutation site of one base substitution mutation highly correlated with fertility, and deficiency or mutation of PGAM4 human gene providing fertility testing kit comprising reagents for detecting the presence of.