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Treatment solution and method for preventing posterior capsule opacity by selectively inducing detachment and / or death of lens epithelial cells
Treatment solution and method for preventing posterior capsule opacity by selectively inducing detachment and / or death of lens epithelial cells
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机译:通过选择性诱导晶状体上皮细胞脱离和/或死亡来预防后囊混浊的治疗溶液和方法
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摘要
A treatment solution used to prevent posterior capsular opacification is applied or introduced into the lens capsular bag before, during, or after cataract surgery. The treatment solution may also be applied to the intraocular lens prior to surgery. The treatment solution comprises an ion transport mechanism interference agent, which either alone or in combination with other treatment agents such as an osmotic stress agent to establish a suitable pH, selectively induces detachment and/or death of lens epithelial cells such that posterior capsular opacification is prevented. While the ion transport mechanism interference agent is capable of interfering with the cellular mechanisms and cell ion distribution of a broad range of cells, a concentration of agent is selected such that the treatment solution interferes selectively with the cellular mechanisms of lens epithelial cells while leaving other ocular cells substantially unharmed. The treatment solution selectively induces cellular death and/or detachment of lens epithelial cells while other ocular cells and tissue substantially unharmed and without lengthy preoperative pretreatment.
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