It has at least one of cell growth promotion activity, angiogenesis promotion activity, tube formation promotion activity, cell migration promotion activity and nerve cell growth promotion activity, and is a chemically stable low molecular weight substance, because of its low molecular weight, Provided is a compound that has high absorbability and can be stably supplied at low cost. The cyclobutylpurine derivative of the present invention, a tautomer or stereoisomer thereof, or a salt, solvate or hydrate thereof is a cyclobutylpurine derivative represented by the following general formula (1), or a tautomer thereof. Or a stereoisomer, or a salt, solvate or hydrate thereof.
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