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Method for diagnosing non-small cell lung cancer by tRNA-dihydrouridine synthase activity of URLC8
Method for diagnosing non-small cell lung cancer by tRNA-dihydrouridine synthase activity of URLC8
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机译:URLC8的tRNA-二氢尿苷合酶活性诊断非小细胞肺癌的方法
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摘要
The present invention features a method for determining t-RNA dihydrouridine-synthase activity of a polypeptide and screening for modulators of t-RNA dihydrouridine-synthase activity. The present invention further provides methods or pharmaceutical compositions for preventing and/or treating non-small cell lung cancer (NSCLC) using such modulators. Furthermore, the present invention provides methods for diagnosing non-small cell lung cancer (NSCLC) using the t-RNA dihydrouridine-synthase activity of IMS-E21 (URLC8) protein as an index. The present invention further provides methods for predicting and prognosing lung squamous-cell carcinoma (SCC).
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