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Spatial Biomarker of Disease and Detection of Spatial Organization of Cellular Receptors
Spatial Biomarker of Disease and Detection of Spatial Organization of Cellular Receptors
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机译:疾病的空间生物标志物和细胞受体的空间组织检测
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摘要
A signature of a condition of a live cell is established in an assay that allows distribution of the receptors on the cell surface in response to binding a ligand. The receptors can be optically detected and quantified to provide a value for the condition, Test drugs can be screened for therapeutic potential in the assay: a potentially efficacious drug is identified by an ability to modulate an established signature. The receptor distribution signature can be corroborated with an mRNA expression profile of several genes, indicating, for example, metastasis.
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