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Novel Porcine Circovirus Type 2B Isolate and Uses Thereof

机译:新型猪圆环病毒2B型分离株及其用途

摘要

The present invention relates to the novel Porcine Circovirus type 2 subtype B (PCV2B-Rm) isolate which comprises a short duplication of sequence and is adapted to grow in cell culture and may be propagated at high titres constantly up to 106 TCID50 viral particles per mL. This novel isolate is particularly useful for the production of porcine circovirus type 2 (PCV2) vaccines, for treating and/or preventing and/or diagnosing porcine circovirus associated diseases, as well as for diagnosing the presence of porcine circovirus in pigs. The present invention also relates to novel cell clones derived from Swine Testicles (ST) useful for propagating PCV2 and to a method for production of PCV2 virus with particularly high titers.
机译:本发明涉及新颖的猪圆环病毒2型B亚型(PCV2B-Rm)分离株,该分离株包含短重复序列并适于在细胞培养物中生长,并且可以高滴度不断地繁殖直至10 6。 / Sup> TCID 50 病毒颗粒/ mL。这种新型分离物特别适用于生产猪圆环病毒2型(PCV2)疫苗,治疗和/或预防和/或诊断与猪圆环病毒有关的疾病,以及诊断猪中猪圆环病毒的存在。本发明还涉及衍生自猪睾丸(ST)的新型细胞克隆,其用于繁殖PCV2,并且涉及生产具有特别高滴度的PCV2病毒的方法。

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