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ZNF206: A NOVEL REGULATOR OF EMBRYONIC STEM CELL SELF-RENEWAL AND PLURIPOTENCY
ZNF206: A NOVEL REGULATOR OF EMBRYONIC STEM CELL SELF-RENEWAL AND PLURIPOTENCY
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机译:ZNF206:胚胎干细胞自我更新和免疫力的新型调节剂
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摘要
We have identified ZNF206, a novel repressor of human embryonic stem cell (hESC) differentiation. Repressing extra-embryonic endoderm development preserves the pluripotent state of human embryonic stem cells, and, conversely down-regulating expression of ZNF206 in hESCs causes them to upregulate the expression of genes associated with the extra-embryonic endodermal lineage, down-regulate genes associated with the pluripotent state, and may lead to the further emergence of genes associated with even more differentiated lineages and phenotypes.
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