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Amphiphilic molecule, molecular assembly comprising the amphiphilic molecule, and use of the molecular assembly

机译:两亲性分子,包含该两亲性分子的分子组装体以及该分子组装体的用途

摘要

The present invention provides an amphiphilic molecule having a plurality of zwitterionic functional groups in its hydrophilic moiety and a molecular assembly comprising the amphiphilic molecule as a constituent lipid. The molecular assembly of the present invention forms a stable vesicular structure under a physiological pH environment to carry a substance of interest in the vesicular structure, and can release the substance of interest to the outside of the vesicular structure when it is deformed under an acidic pH environment. The molecular assembly of the present invention can be used as a carrier for a drug, a probe, a nucleic acid, a protein or the like.
机译:本发明提供在其亲水性部分中具有多个两性离子官能团的两亲性分子以及包含该两亲性分子作为构成脂质的分子组装体。本发明的分子组装体在生理pH环境下形成稳定的囊泡结构以在囊泡结构中携带目标物质,并且当其在酸性pH下变形时可以将其释放到囊泡结构的外部。环境。本发明的分子组装体可以用作药物,探针,核酸,蛋白质等的载体。

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