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Genomic Transcriptional Analysis as a Tool for Identification of Pathogenic Diseases
Genomic Transcriptional Analysis as a Tool for Identification of Pathogenic Diseases
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机译:基因组转录分析作为鉴定致病性疾病的工具
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摘要
The discovery and validation of a candidate biomarker signature for the diagnosis of sepsis, and more particularly septicemic meliodiosis, based on genomic transcriptional profiling using microarrays is described herein. The microarray technology of the instant invention generates genome-wide transcriptional profiles (48,000 transcripts) from the whole blood of patients with septicemic melioidosis (n=32), patients with sepsis caused by other pathogens (n=31), and uninfected controls (n=29). Unsupervised analyses demonstrated the existence of a whole blood transcriptional signature distinguishing patients with sepsis from control subjects.
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机译:本文描述了基于使用微阵列的基因组转录谱分析的发现和验证候选生物标志物签名的诊断和败血症的诊断,更具体地,败血病性减数分裂的诊断。本发明的微阵列技术从败血性类鼻疮病患者(n = 32),其他病原体引起的败血症患者(n = 31)和未感染的对照( n = 29)。无监督分析表明存在全血转录特征,将败血症患者与对照患者区分开。
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