GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH CALIBRATION CHAMBER CONTAINING PROBE DESIGNED TO BE NONCOMPLEMENTARY TO NUCLEIC ACID SEQUENCES IN THE AMPLICON

摘要

A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing a target nucleic acid sequences, a hybridization chamber containing probes each having a nucleic acid sequence for hybridization with the target nucleic acid sequences to form probe-target hybrids, and, a calibration chamber containing a control probe incapable of hybridization with any sequence in the biological sample.