首页>
外国专利>
Multiparticle pharmaceutical dosage form for a low-soluble active substances and method for producing said pharmaceutical dosage form
Multiparticle pharmaceutical dosage form for a low-soluble active substances and method for producing said pharmaceutical dosage form
展开▼
机译:用于低溶解性活性物质的多颗粒药物剂型及其制备方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention relates to an oral multiparticle pharmaceutical dosage form in the form of a receptacle reducing the pH values of stomach, containing a plurality of pellets, particles, granules or agglomerates whose mean diameter ranges from 50 to 2500 μn substentially consisting of a) an internal matrix layer containing an active agent which is neither peptide or protein, nor the derivatives or conjugates thereof, a lipophilic matrix whose melting point is greater than 37° C. and a polymer with mucoadhesive effect, b) an external film coating substentially consisting of a polymer or an anionic copolymer which is optionally formulated with conventional pharmaceutical additives, wherein the active agent has a water solubility according to DAB 10, of at least 30 volume parts of water for one part by weight of the active agent and is coated with the lipophilic matrix and said active agent-containing lipophilic matrix is coated with a matrix made of a polymer with mucoadhesive effect. A method for producing the inventive multiparticle pharmaceutical dosage is also disclosed.
展开▼