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Method for the use of 11C carbon monoxide in labeling synthesis of 11C-labelled ketones by photo-induced free radical carbonylation
Method for the use of 11C carbon monoxide in labeling synthesis of 11C-labelled ketones by photo-induced free radical carbonylation
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机译:[11C]一氧化碳在光诱导的自由基羰基化标记合成11C标记的酮中的使用方法
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摘要
Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with carbanion precursors pretreated by a base are provided. The resultant carbon-isotope labeled ketones, and pharmaceutical acceptable salts and solvates are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits and method for PET studies are also provided.
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