Methods and systems for determining a sequence of energy interactions in a detector. A plurality of discrete energy interactions is received in a plurality of detector voxels. A plurality of possible sequences of interaction is formed based on the received plurality of discrete energy interactions. For each of the plurality of possible sequences of interaction, an a posteriori probability is computed, where the a posteriori probability is based on a likelihood that the possible sequence of interaction is consistent with the received plurality of discrete energy interactions. Additionally or alternatively, the a posteriori probability may be based on an a priori probability. One of the formed plurality of possible sequences of interaction is selected based on the computed a posteriori probability.
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