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GENE TRANSFER VECTORS COMPRISING GENETIC INSULATOR ELEMENTS AND METHODS TO IDENTIFY GENETIC INSULATOR ELEMENTS
GENE TRANSFER VECTORS COMPRISING GENETIC INSULATOR ELEMENTS AND METHODS TO IDENTIFY GENETIC INSULATOR ELEMENTS
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机译:包含遗传绝缘子元素的基因转移载体和鉴定遗传绝缘子元素的方法
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摘要
The present invention relates to a gene transfer vector (GTV) and in particular to an integrating gene transfer vector (IGTV), which comprises at least one genetic insulator element (GIE), wherein the each comprises at least two copies of an element selected from the group consisting of: a CTF binding site; a first CTCF binding site and a second CTCF binding site, wherein the first and the second CTCF binding sites are derived from the regulatory sequences of different genes.
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