Nucleic acid sequences comprising NF-κB binding site within O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter region and uses thereof for the treatment of cancer and immune-related disorders

摘要

The invention relates to nucleic acid sequences comprising NF-κB binding sites derived from the MGMT promoter region and uses thereof as decoy molecules in the treatment of cancer and immune-related disorders. More particularly, the invention relates to nucleic acid sequences as well as to modified oligonucleotides (ODNs) comprising NF-κB binding sites derived from the MGMT promoter region, and uses thereof as decoy molecules for inhibiting NF-κB enhanced expression of MGMT. The invention further relates to compositions, kits and screening methods using the NF-κB binding sites of the invention or ODNs comprising the same for treating cancer and immune related disorders.