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Methods and compositions for detecting and treating retinal diseases based on metargidin (ADAM-15)
Methods and compositions for detecting and treating retinal diseases based on metargidin (ADAM-15)
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机译:基于美格他定(ADAM-15)的视网膜疾病的检测和治疗方法及组合物
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摘要
The invention discloses multiple genes related to age-related macular degeneration (AMD) and/or phagocytosis by RPE cells of the eye, and methods and compositions for detecting and treating AMD and other retinal degenerative conditions based on these phagocytosis-related and/or AMD-related genes. Also provided are animal models useful for testing therapeutic compounds and treatment protocols for AMD, and gene arrays including polymorphic variants of phagocytosis-related and/or AMD-related genes, useful for genetic screening of nucleic acid samples from subjects to obtain profiles of polymorphic variant sequences in a plurality of genes associated with AMD.
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