A method for establishing multiple look-up tables and a data acquisition method using multiple look-up tables are provided. In the present method, a plurality of input data is classified into a plurality of groups, and a plurality of input data and a plurality of output data corresponding to the input data are respectively provided to the groups to establish a plurality of corresponding look-up tables. At least one bit is selectively removed from the input data in each of the look-up tables corresponding to at least one of the groups, and the result input data and the corresponding output data are recorded in the look-up table corresponding to the group.
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