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Cis-2, 6-disubstituted tetrahydropyran derivatives and preparation method thereof
Cis-2, 6-disubstituted tetrahydropyran derivatives and preparation method thereof
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机译:cis-2,6-二取代的四氢吡喃衍生物及其制备方法
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摘要
Disclosed are cis-2,6-disubstituted tetrahydropyran derivatives represented by Chemical Formula 1 and a preparation method thereof. The tetrahydropyran derivatives can be prepared by Prins-reacting tetrahydropyran derivatives with homopargylicalcohol derivatives in the presence of trimethylsilyltriflate. The tetrahydropyran derivatives with cis-substituents at both C2 and C6 positions of the tetrahydropyran ring are useful as intermediates for use in the synthesis and development of therapeutically effective, naturally occurring compounds.; ;(wherein, R1, R2 and R3 are as defined in the specification.).
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