Method and System for Quantitative Cell Nuclei Arrangement Measure in Histological Tissue Using Structural Entropy

摘要

A method for measuring structural entropy of cell nuclei in a histological micrograph of a biopsy tissue sample involves the steps of: obtaining a dye color map from a color image of the biopsy tissue sample; locating cell nuclei in the dye color map; and measuring structural features within small groups (cliques or paths) of cell nuclei to determine their degree of organization (or structural entropy). Also, an apparatus for measuring structural entropy of cell nuclei in a histological micrograph of a biopsy tissue sample includes a processor executing instructions for: obtaining a dye color map of the biopsy tissue sample; locating cell nuclei in the dye color map; and measuring structural features within small groups (cliques or paths) of cell nuclei to determine their degree of organization (or structural entropy).