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Animal model having a chimeric human liver and susceptible to human hepatitis C virus infection
Animal model having a chimeric human liver and susceptible to human hepatitis C virus infection
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机译:具有嵌合人类肝脏并易感染人类丙型肝炎病毒的动物模型
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摘要
The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. The animals of the invention are also useful in assessing toxicity of various agents, as well as the activity of agents in decreasing blood lipids.
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