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Beta helical peptide structures stable in aqueous and non-aqueous media and methods for preparing same
Beta helical peptide structures stable in aqueous and non-aqueous media and methods for preparing same
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机译:在水和非水介质中稳定的β螺旋肽结构及其制备方法
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摘要
Disclosed is a method of making peptide structures that are stable in aqueous and non-aqueous media where a first linear peptide chain comprising alternating D,L- or L,D-amino acids having an N and C termini is joined by at least one turn region to a second linear peptide chain comprising alternating D,L- or L,D-amino acids having an N and C termini. The peptide chains can be joined at the C terminus of one of the linear peptide chains with an N terminus of the other linear peptide chain, a C terminus of one of the linear peptide chains with a C terminus of the other linear peptide chain, or an N terminus of one of the linear peptide chains with an N terminus of the other linear peptide chain.
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