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Preparative-scale separation of enantiomers of chiral carboxylic acids
Preparative-scale separation of enantiomers of chiral carboxylic acids
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机译:制备规模的手性羧酸对映异构体的分离
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摘要
High yields and purity are obtained in the purification of enantiomers of chiral carboxylic acids by preparative-scale chromatography by including a tertiary alcohol in the mobile phase in conjunction with an acidic modifier and a hydrophobic solvent. The tertiary alcohol is superior to other, more commonly used alcohols by reducing the extent of esterification of the enantiomer that otherwise lowers the yield and the purity.
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