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Method for treating idiopathic thrombocytopenic purpura using monoclonal antibodies

机译：用单克隆抗体治疗特发性血小板减少性紫癜的方法

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摘要

The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcγ receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunization in Rh negative persons, in particular for haemolytic disease in a new-born baby or for uses such as idiopathic thrombocytopenic purpura (ITP).

机译：本发明涉及通过ADDC型测试获得和选择单克隆抗体的方法，所述抗体能够激活III型Fcγ受体并具有特定的聚糖结构。本发明的抗D抗体可用于预防Rh阴性人群的恒河猴同种免疫，特别是用于新生婴儿的溶血性疾病或用于例如特发性血小板减少性紫癜（ITP）。

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公开/公告号US8124078B2

专利类型
公开/公告日2012-02-28

原文格式PDF
申请/专利权人 ROLAND BELIARD;DOMINIQUE BOUREL;ARNAUD GLACET;CHRISTOPHE DE ROMEUF;NICOLAS BIHOREAU;EMMANUEL NONY;
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申请/专利号US20090502911
发明设计人 ROLAND BELIARD;DOMINIQUE BOUREL;ARNAUD GLACET;CHRISTOPHE DE ROMEUF;NICOLAS BIHOREAU;EMMANUEL NONY;
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申请日2009-07-14
分类号A61K39/395;
国家 US
入库时间 2022-08-21 17:26:51

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