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Automated analysis system for detection and quantification of biomolecules by measurement of changes in liquid crystal orientation
Automated analysis system for detection and quantification of biomolecules by measurement of changes in liquid crystal orientation
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机译:自动化分析系统,用于通过测量液晶方向的变化来检测和定量生物分子
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摘要
The present invention provides systems and methods for data acquisition and image analysis that utilize twisted nematic liquid crystals (“TNLCs”) to create maps of bio/chemical functionality patterned on surfaces. The method involves the acquisition of a series of images of TNLC film that contacts the analytic surface followed by analysis of the series of images to yield maps of twist angle of the liquid crystal across the surface. This analysis technique effectively condenses a large data set (stack of images) into a compact form (map of twist angle), revealing features on the surface that were not apparent in the individual images comprising the original stack.
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