Method of assessing the proliferation or differentiation behaviour of a population of target cells in a biological system

摘要

The invention relates to a method of assessing the proliferation or differentiation behavior of a population of target cells in a biological system, said method comprising the steps of; [a] measuring the value of at least one proliferation characteristic of said cells at least one time point t, wherein said proliferation characteristic is the clone size distribution; [b] comparing the clone size distribution measured in [a] to a reference clone size distribution at a corresponding time point t predicted or described by the equation; wherein a difference between the measured clone size distribution of [a] and the predicted or described clone size distribution of [b] indicates an altered proliferation or differentiation behavior of said cells. The invention further relates to methods involving assessing the scaling form of the above behaviors, values of the parameters, and inferring effects on cell proliferation and/or differentiation therefrom.