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Antibody to a guanine nucleotide exchange factor
Antibody to a guanine nucleotide exchange factor
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机译:鸟嘌呤核苷酸交换因子的抗体
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摘要
A gene encoding a novel protein that works as a guanine nucleotide exchange factor (GEF) for a Rho family protein being one group of small GTP-binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.
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机译:编码一种新型蛋白质的基因,该蛋白质可作为一组小的GTP结合蛋白的Rho家族蛋白的鸟嘌呤核苷酸交换因子(GEF),即由SEQ ID NO:1所示核苷酸序列显示的多核苷酸SEQ ID NO:3或SEQ ID NO:5,或互补链,多核苷酸的等价物,由多核苷酸编码的蛋白质,包含多核苷酸的载体,包含该载体的转化体,针对由本发明提供了一种多核苷酸,鉴定抑制多核苷酸编码的蛋白质的功能和/或多核苷酸表达的化合物的方法,确定疾病的方法,药物组合物和试剂盒。
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