首页> 外国专利> Synthesis and evaluation of ¹⁸F-labelled-alkyl-1-(1R)-1-phenylethyl-1H-imidazole-5-carboxylate as a tracer for the quantification of β-11-hydroxylase enzyme in the adrenal glands

Synthesis and evaluation of ¹⁸F-labelled-alkyl-1-(1R)-1-phenylethyl-1H-imidazole-5-carboxylate as a tracer for the quantification of β-11-hydroxylase enzyme in the adrenal glands

机译：^{18 F标记的烷基-1-[（（1 R ）-1-苯乙基] -1 H -咪唑- 5-羧酸盐作为肾上腺中β-11-羟化酶定量的示踪剂}

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Radioactively labeled derivatives of (R)-3-(1-phenylethyl)-3H-imidazole-4-carboxylic acid esters and one-step methods for preparing these compounds are provided. The radioactively labelled compounds, and pharmaceutical acceptable salts and solvates are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET) for the diagnosis of adrenal cortical masses such as incidentaloma, adenoma, primary and metastatic cortical carcinoma. Associated kits and method for PET studies are also provided. 展开▼

机译：提供了（R）-3-（1-苯乙基）-3H-咪唑-4-羧酸酯的放射性标记衍生物和制备这些化合物的一步法。放射性标记的化合物以及药学上可接受的盐和溶剂化物可用作放射性药物，特别是用于正电子发射断层扫描（PET）中以诊断肾上腺皮质块，例如偶发瘤，腺瘤，原发性和转移性皮癌。还提供了用于PET研究的相关试剂盒和方法。展开▼

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公开/公告号US8071785B2

专利类型

公开/公告日2011-12-06

原文格式PDF

申请/专利权人 BENGT LANGSTROM;FARHAD KARIMI;ELISABETH BLOM;MARIA ERLANDSSON;
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申请/专利号US20070303290

发明设计人 BENGT LANGSTROM;FARHAD KARIMI;ELISABETH BLOM;MARIA ERLANDSSON;
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申请日2007-06-07

分类号C07D233;

国家 US

入库时间 2022-08-21 17:25:43

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机译： 18 F-标记的烷基-1-[（R）-1-苯乙基] -1H-咪唑-5-羧酸酯的合成与评价作为痕量肾上腺β-11-羟化酶的示踪剂

4. SYNTHESIS AND EVALUATION OF 18F-LABELLED ALKYL-1-(R)-1-PHENYLETHYL-1H-IMIDAZOLE-5-CARBOXYLATE AS A TRACER FOR THE QUANTIFICATION OF β-11-HYDROXYLASE ENZYME IN THE ADRENAL GLANDS [P] . 世界知识产权组织专利： WO2007144725A2 . 2007-12-21

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机译： 18 F-标签烷基-1-[（（1R）-1-苯基乙基] -1H-咪唑-5-羧酸酯的合成和评价）作为痕量β11-11-羟化酶在肾上腺的定量示踪剂

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Synthesis and evaluation of 18F-labelled-alkyl-1-(1R)-1-phenylethyl-1H-imidazole-5-carboxylate as a tracer for the quantification of β-11-hydroxylase enzyme in the adrenal glands

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Synthesis and evaluation of ¹⁸F-labelled-alkyl-1-(1R)-1-phenylethyl-1H-imidazole-5-carboxylate as a tracer for the quantification of β-11-hydroxylase enzyme in the adrenal glands