Ophthalmic Liquid formulation comprising substituted gamma lactams, includes the article of manufacture and its use for the preparation of a Medicament useful for treating ocular hypertension

摘要

A topical formulation comprising at least a therapeutically Active agent at a concentration of 0.01 to 0.12% (W / V) in a vehicle Liquid ophthalmic acceptable from the point of view, where the active agent has the formula (1) or a pharmaceutically acceptable Salt thereof, where Is - (CH2) 6 -, cis - ch2ch = CH - (CH2) 3 -, or - CH2C: C - (CH2) 3 -Where one or two fractions of CH2 can be replaced with s or; or is - (CH2) M - (CH2) or ar - AR -, where is interarileno or heterointerarileno, or is the sum of M and 1 to 4, and where one or two fractions of CH2 can be replaced with S U h, or C1, R1 is alkyl or aryl optionally - 6 and B is its Replace or optionally substituted heteroaryl.Article of manufacture comprises a container adapted to manage content in controlled manner, where the contents of the container comprises the ophthalmic formulation is described. Use of the Formulation for the preparation of a Medicament useful for treating ocular hypertension.