bioerodible composition for the administration of a bioactive agent, kit for the formation of a bioerodible composition, methods of producing a bioerodible solidified composition for the administration of a bioactive agent, production of a bioerodible fiber for the administration of a bioactive agent and formation of a bioerodible film for the administration of a bioactive agent, implantable medical device, and method of administration of a bioactive agent to a body site in need thereof

摘要

BIOERODIBLE COMPOSITION FOR THE ADMINISTRATION OF A BIOACTIVE AGENT, KIT FOR FORMATION OF A BIOERODIBLE COMPOSITION, METHODS OF PRODUCTION OF A BIOERODIBLE COMPOSITION FOR THE ADMINISTRATION OF A BIOACTIVE ADDITIONAL ADMINISTRATOR IMPLANTABLE DOCTOR, AND METHOD OF ADMINISTRATION OF A BIOACTIVE AGENT TO A BODY SITE NEEDING IT. A bioerodible composition for providing a bioactive agent is the reaction product of a reaction mixture including an oxidized dextrate solution, and a solid mixture containing a dihydrazide, a bioactive agent, and optionally a ph adjusting agent. in an amount sufficient to produce a reaction mixture ph of 6 or less. The composition may include a release agent for the controlled release of the bioactive agent from the composition. The bioactive agent may therefore be delivered to the body site in need thereof by providing a first aliquot portion of a reaction mixture by providing a first aliquot portion of a reaction mixture composed of an oxidized dextrate solution. , and a second aliquot portion of a reaction mixture composed of a mixture of solids composed of a dihydrazide, a bioactive agent, and a solid acid which is present in a quantity sufficient to produce a reaction mixture ph of 6 or memos, mixing the first and second aliquot portions to form the reaction mixture thereof, and then installing the reaction mixture at the body site, allowing a bioerodible drug delivery composition to be formed in situ thereof. . The present invention may be presented in the form of a kit consisting of a double syringe containing respectively the first and second aliquots of the reaction mixture so that they may be mixed immediately prior to use.