analogues of arylpropionamide, arylacrylamide, arylpropinamide, or arylmethylurea analogues, processes for their preparation, pharmaceutical composition and use thereof

摘要

ANALOG COMPOUNDS OF ARILPROPIONAMIDE, ARILACRILAMIDE, ARILPROPINAMIDE, OR ARYLMETHYLERIA, PROCESS FOR THE PREPARATION, PHARMACEUTICAL COMPOSITION AND USE OF THE SAME. The present invention provides compounds according to Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L ~ 1, M and R 11 are as defined. on here. The compounds according to Formula (I) are selective inhibitors of serine protease enzymes of the coagulation cascade and / or contact activation system; for example thrombin, factor Xa, factor Xla, factor IXa, factor VIla and / or plasma kallikrein. In particular, it refers to compounds which are selective factor X1a inhibitors or dual plasma inhibitors of fX1a and kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and / or inflammatory disorders using them.