aqueous pharmaceutical formulation, exendin dosage form, aqueous solution, use of a pharmaceutical formulation, and use of an aqueous pharmaceutical formulation

摘要

WATER PHARMACEUTICAL FORMULATION, EXENDIN DOSAGE FORM, WATER SOLUTION, USE OF A PHARMACEUTICAL FORMULATION, AND USE OF A WATER PHARMACEUTICAL FORMULATION. What is described is a pharmaceutical formulation for intranasal administration of exendin to a mammal, where the formulation comprises a therapeutically effective amount of an exendin, a viscosity enhancer, methyl- 225 cyclodextrin, a surfactant, tartrate buffer to control pH and a chelating agent for cations, and where such exendin dosage form exhibits at least 95% recovery of exenatide after at least 365 days stored at 5 198 C.