purified polypeptide, isolated nucleic acid molecules, isolated cell, method for producing a polypeptide, composition, methods for inhibiting microbial growth, manufactured article and purified antibody

摘要

PURIFIED POLYPEPTIDE, ISOLATED NUCLEIC ACID MOLECULES, ISOLATED CELL, METHOD TO PRODUCE A POLYPEPTIDE, COMPOSITION, METHODS TO INHIBIT MICROBIAN GROWTH, MANUFACTURED AND PURIFIED ANTIBODY. The invention relates to the antimicrobial polypeptides catelicidin related to a 38 amino acid peptide having SEQ ID No: 4. The invention provides polypeptides that have broad spectrum antimicrobial activity, nucleic acids and expression of vectors that encode these polypeptides, as well as cells hosts and methods to reduce the survival of a microbe. In addition, the invention also provides compositions, as well as manufactured articles, which comprise a broad spectrum antimicrobial polypeptide.