methods of isomerizing a solution of a vitamin d derivative to produce and prepare calcipotriol or calcipotriol monohydrate, and for the manufacture of a pharmaceutical formulation or medicament, and use of a direct flow photoreactor or photoreactor continuous flow

摘要

METHODS OF ISOMERIZATION OF A SOLUTION OF A VITAMIN D DERIVATIVE, FOR THE PRODUCTION AND PREPARATION OF CALCIPOTRIOL OR CALCIPOTRIOL MONOIDRATE, AND FOR THE MANUFACTURE OF A PHARMACEUTICAL OR MEDICATION FORMULATION, AND, USE OF A PHOTO-REACTOR REACTOR CONTINUOUS FLOW. The present invention relates to a method of isomerization of vitamin D analogs, such as compounds useful for the synthesis of calcipotriol, and the use of a flow through a photo-reactor or a continuous-flow photo-reactor for the production of said vitamin D analogs. The present invention also relates to the use of intermediates produced with said method to produce calcipotriol or calcipotriol monohydrate, or pharmaceutical formulations thereof.