Use of colchicine or thiocolchicin protein-carrier and dimer, dosage unit form, pharmaceutical composition and kits

摘要

USES OF VEHICLE PROTEIN AND DIMERO OF COLCHICINE OR THIOCOLCHICINE, UNIT FORM OF DOSAGE, PHARMACEUTICAL COMPOSITION AND KITS. The present invention relates to methods of inhibiting anglogenesis in an individual by administering a composition (such as a protein containing composition) comprising coichicin or thiocyclicin dimer. The composition is in an amount that is effective in inhibiting angiogenesis but is in some embodiments insufficient to induce significant cytotoxicity in the subject. The methods described herein are useful for treating angiogenesis-associated diseases such as age-related macula degeneration, retinopathy. diabetic, rheumatic arthritis, psoriasis, and cancer.