process for the synthesis of a substantially pure stereoisomer, compounds, pharmaceutical composition comprising a compound, process for the synthesis of a compound and use thereof.

摘要

UM PROCESS FOR SYNTHESIS OF A SUBSTANTIALLY PURE COMPOUND STEREOSISM, PHARMACEUTICAL COMPOSITION UNDERSTANDING A COMPOUND, PROCESS FOR SYNTHESIS OF A COMPOUND AND USE OF THEM MV New pyrogen-glutamic acid derivatives are exposed wherein R1 is -OH, -ORa, wherein Ra is alkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, aralkyl or heterocyclyl; R 2, R 3 and R 4 are independently H, a nitrogen protecting group that hydrolyzes under acidic or phthalamide conditions; X is a pharmaceutically acceptable anion; and Y is a group containing N; whether in the form of their optically active stereoisomers alone or in the form of mixtures thereof, are compounds useful for enhancing an immunoresponse in a patient and / or for treating tumors, bacteria, fungal or virus infections, or autoimmune diseases.